کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8329895 1540238 2016 36 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biocompatible and biodegradable poly(Tannic Acid) hydrogel with antimicrobial and antioxidant properties
ترجمه فارسی عنوان
هیدروژل پلی (تاننیک اسید) بیو سازگار و تجزیه پذیر با خواص ضد میکروبی و آنتی اکسیدانی
کلمات کلیدی
اسید تانیک، هیدروژل ضد میکروبی / آنتی اکسیدان، فیلم بی نظیر / بیو سازگار با فیلم فوق العاده،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
A novel resourceful bulk poly(Tannic Acid) (p(TA)) hydrogel was prepared by crosslinking TA molecules with an epoxy crosslinker, trimethylolpropane triglycidyl ether (TMPGDE), in an autoclave at 90 °C for 2 h. The obtained p(TA) hydrogels were in disk form and have highly porous morphology. The swelling characteristics of p(TA) hydrogels were investigated in wound healing pH conditions of pH 5.4, 7.4, and 9 at 37.5 °C, and the hydrogels showed good swelling and moisture content behavior. Especially, p(TA) hydrogels were found to be sensitive to pH 9 with 1669% maximum swelling. P(TA) hydrogels were completely degraded at pH 9 hydrolytically in 9 days. Total phenol contents and the effects of scavenging ABTS+ radicals of degraded p(TA) hydrogels at pH 5.4, 7.4, and 9 were evaluated and calculated in terms of gallic acid equivalent and trolox equivalent antioxidant capacity, respectively, and found to be very effective. Moreover, degraded p(TA) hydrogels display strong antimicrobial behavior against gram positive Staphylococcus aureus, Bacillus subtilis, gram negative Pseudomonas aeruginosa bacteria strains and Candida albicans fungus strain. The WST-1 results indicated that bulk p(TA) hydrogels have no cyctotoxicity to the L929 fibroblast cell line in vitro.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 82, January 2016, Pages 150-159
نویسندگان
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