Assessment of structure, stability and aggregation of soluble lens proteins and alpha-crystallin upon non-enzymatic glycation: The pathomechanisms underlying cataract development in diabetic patients

- Total soluble lens proteins and α-crystallin were extensively glycated.
- The protein glycation was confirmed by different methods.
- Glycated crystallins indicate higher conformational stability than non-glycated protein counterparts.
- Glycation causes crystallins to resist against stress-induced unfolding and aggregation.