کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8330262 1540238 2016 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microwave-assisted synthesis of porous chitosan-modified montmorillonite-hydroxyapatite composite scaffolds
ترجمه فارسی عنوان
سنتز میکروویو با استفاده از داربست کامپوزیت مونتموریلونیت-هیدروکسی آپاتیت اصلاح شده متشکل از کیتوزان متخلخل
کلمات کلیدی
کیتوزان، هیدروکسی آپاتیت، مونتموریلونیت،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
In this study, a porous chitosan-organically modified montmorillonite-hydroxyapatite (CS-OM-HA) composite scaffold was developed by combining microwave irradiation and gas foaming method. Hydroxyapatite (HA) particles of size ∼65 nm were synthesized and characterized by X-ray diffraction (XRD) and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy. The prepared composite scaffolds were characterized using ATR-FTIR, XRD, mercury intrusion porosimeter (MIP) and scanning electron microscopy (SEM) studies. The synergistic effect of HA and OM on the mechanical and in vitro biological properties (swelling, degradation, protein adsorption and bioactivity) of the composite scaffolds were evaluated. Swelling, degradation, mechanical property, bioactivity and protein adsorption studies of CS-OM-HA composite scaffolds have shown desirable results in comparison with the pure CS and CS-OM composite scaffolds. CS-OM-HA composite scaffolds were also found to be non-cytotoxic to MG 63 osteoblast cell lines. From the study, it can be concluded that the novel CS-OM-HA composite scaffold with improved mechanical and in vitro biological properties has wide potential in non-load bearing bone tissue engineering applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 82, January 2016, Pages 628-636
نویسندگان
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