کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8330410 | 1540239 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-diabetic properties of Momordica charantia L. polysaccharide in alloxan-induced diabetic mice
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کلمات کلیدی
MCPPMPBGLMomordica charantia L.1-phenyl-3-methyl-5-pyrazoloneHypoglycemic effect - اثر هیپوگلیسمیblood glucose level - سطح قند خونAnti-diabetic - ضد دیابتMolecular weight - وزن مولکولیPolysaccharide - چندقندی ها یا پلیساکاریدهاhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کارا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A water-soluble polysaccharide (MCP) was isolated from the fruits of Momordica charantia L., and the hypoglycemic effects of MCP were investigated in both normal healthy and alloxan-induced diabetic mice. MCP was orally administered once a day after 3 days of alloxan-induction at 100, 200 and 300Â mg/kg body weight for 28 day. Results showed that fasting blood glucose level (BGL) was significantly decreased, whereas the glucose tolerance was marked improvement in alloxan-induced diabetic mice, and loss in body weight was also prevented in diabetic mice compared to the diabetic control group. The dosage of 300Â mg/kg body weight exhibited the best effects. In addition, MCP did not exhibit any toxic symptoms in the limited toxicity evaluation in mice. The results suggest that MCP possess significantly dose-dependent anti-diabetic activity on alloxan-induced diabetic mice. Hence, MCP can be incorporated as a supplement in health-care food, drugs and/or combined with other hypoglycemic drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 81, November 2015, Pages 538-543
Journal: International Journal of Biological Macromolecules - Volume 81, November 2015, Pages 538-543
نویسندگان
Xin Xu, Bin Shan, Cai-Hu Liao, Jian-Hua Xie, Ping-Wei Wen, Jia-Yi Shi,