کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8330499 | 1540240 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of Bush Sophora Root polysaccharide and its sulfate on immuno-enhancing of the therapeutic DVH
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کلمات کلیدی
DMEMVirus controlDVHDEHshelper TDHAVDuck hepatitis A virusHGFIFN-γPhytohemagglutininPHALPSnatural killer - (سلول های) کشنده طبیعیDulbecco's modified Eagle Medium - Eagle Medium اصلاح شده Dulbeccoantibodies - آنتی بادی هاinterleukin - اینترلوکینHepatocyte growth factor - عامل رشد هپاتوسیتlipopolysaccharide - لیپوپلی ساکاریدMaintenance medium - متوسط نگهداریblank control - کنترل خالیcell control - کنترل سلولInterferon gamma - گاما اینترفرون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of Bush Sophora Root polysaccharide and its sulfate on immuno-enhancing of the therapeutic DVH Effects of Bush Sophora Root polysaccharide and its sulfate on immuno-enhancing of the therapeutic DVH](/preview/png/8330499.png)
چکیده انگلیسی
Bush Sophora Root polysaccharide (BSRPS) and its sulfate, sulfated Bush Sophora Root polysaccharide (sBSRPS), possess the antiviral activities against duck hepatitis A virus. However their antiviral mechanisms are still not clear. This paper reported their immuno-enhancing roles in the therapeutic effects for duck virus hepatitis (DVH). The effects of BSRPS and sBSRPS on stimulating lymphocyte proliferation were investigated by MTT methods. After that, ducklings were challenged with DHAV and treated with BSRPS and sBSRPS. Meanwhile, the total antibody (Ab), cytokines including interferon gamma (IFN-γ), hepatocyte growth factor (HGF), interleukin (IL)-2, IL-6 and IL-8 were determined by enzyme-linked immuno sorbent assay methods. The results showed that BSRPS owned a fine hepatoprotective effect with stable HGF producing ability. Sulfated modification was able to increase the proliferation rates of B and T lymphocytes and the secretions of total Ab, IFN-γ and IL-2, as comparison with those of BSRPS group. In summary, both of them exhibited immuno-enhancing effects on the therapeutic effects for DVH, and the capacity of sBSRPS was stronger than that of BSRPS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 80, September 2015, Pages 217-224
Journal: International Journal of Biological Macromolecules - Volume 80, September 2015, Pages 217-224
نویسندگان
Yun Chen, Yi Wu, Luanting Xian, Meiyun Song, Ling Zeng, Wen Xiong, Jiaguo Liu, Weidong Sun, Deyun Wang, Yuanliang Hu,