کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8332251 1540246 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A systematic evaluation of hydroxyethyl starch as a potential nanocarrier for parenteral drug delivery
ترجمه فارسی عنوان
ارزیابی سیستماتیک نشاسته هیدروکسی اتیل به عنوان یک نانوساختار بالقوه برای تحویل داروهای تزریقی
کلمات کلیدی
نشاسته هیدروکسید نانوذرات، رسوب گذار، هماهنگی تحویل داروی تزریقی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Development of parenteral nanoformulations is highly challenging due to the stringent demands on stability, reproducibility and high drug loading with minimal excipients. This study focuses on the development of a pharmaceutically acceptable nanomatrix system for parenteral delivery based on Hydroxyethyl Starch (HES), a FDA approved polymer that is relatively unexplored in drug delivery research. HES nanoparticles were prepared through a simple, two-step crosslinking-precipitation route, yielding 160 ± 5 nm, nearly monodispersed spherical particles with high colloidal stability. The utility of this nanocarrier for parenteral delivery was verified by a panel of hemo/cytocompatibility assays at high concentrations (0.05-1 mg/ml) in vitro and in vivo. HES nanomatrix was found effective in encapsulating two chemically distinct drugs having varying hydrophobicities, with the release behavior being influenced by their chemical nature and drug-matrix interactions. Better in vitro efficacy was measured for the nanoencapsulated drug than its bare form, establishing the potential of HES nanocarriers for controlled drug delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 74, March 2015, Pages 575-584
نویسندگان
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