کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8333913 | 1540266 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of viologen-phosphorus dendrimers on acetylcholinesterase and butyrylcholinesterase activities
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of viologen-phosphorus dendrimers on acetylcholinesterase and butyrylcholinesterase activities Effect of viologen-phosphorus dendrimers on acetylcholinesterase and butyrylcholinesterase activities](/preview/png/8333913.png)
چکیده انگلیسی
The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is the first step in checking whether new compounds can be considered as drugs for treating neurodegenerative diseases. The effect of viologen-phosphorus dendrimers on AChE and BChE activities was studied. The results show that the effects on the cholinesterase activities depend on dendrimer type and size. Viologen dendrimers can interact with the enzymes in two ways: they can bind either to a peripheral site of the enzyme or to amino acids located near the active site, inhibiting catalysis by both cholinesterases. All tested non-toxic viologen-phosphorus dendrimers inhibited the activities of both cholinesterases, showing their potential as new drugs for treating neurodegenerative diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 54, March 2013, Pages 119-124
Journal: International Journal of Biological Macromolecules - Volume 54, March 2013, Pages 119-124
نویسندگان
Karol Ciepluch, Monika Weber, Nadia Katir, Anne-Marie Caminade, Abdelkrim El Kadib, Barbara Klajnert, Jean Pierre Majoral, Maria Bryszewska,