Exploiting the synergistic effect of chitosan-EDTA conjugate with MSA for the early recovery from colitis

► Synergistic effect of CH-EDTA (as antibacterial, antifungal agent) and mesalamine was explored for the treatment of colitis. ► CH-EDTA coating optimized employing texture analyzer. ► FTIR, DSC and SEM images suggested high level potential. ► Pharmacokinetic studies showed as an acceptable carrier to deliver drugs to colon. ► CH-EDTA coated MSA tablets showed recovery from TNBS induced colitis.