Antidiabetic activities of oligosaccharides of Ophiopogonis japonicus in experimental type 2 diabetic rats

► We are the first to report the use of OOJ in the treatment of type 2 diabetic rats. ► OOJ exerts remarkable antidiabetic effect. ► OOJ reduces fasting blood glucose level and improves oral glucose tolerance. ► OOJ modulates PEPCK, GCK, glucagon and GLP-1. ► OOJ exhibits neuroprotective effect and enhances insulin activity.