Stability and antioxidant activity of gossypol derivative immobilized on N-polyvinylpyrrolidone

► Water-soluble gossypol derivative conjugated with N-polyvinylpyrrolidone has been synthesized. ► The new gossypol derivative has shown a high antioxidant and antiradical activities. ► Significant protection of mitochondria against oxidative damage in vivo has been demonstrated. ► New water-soluble gossypol derivative can be considered for treatment of diseases that are characterized by oxidative damage.