Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs

► Spermidine inhibited MMP-2 activity and expression. ► The expression levels of histone acetyltransferase, p-ERK, p-JNK MAPK and NF-κB were decreased in the presence of spermidine. ► The expression levels of HDAC1, SIRT1, p-p38 were increased by spermidine.