کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8334468 | 1540272 | 2012 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacological activities of some new polycyclic triazolopyrazolopyridazine derivatives
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
In continuation of our previous work, a novel series of polycyclic derivatives were synthesized and their anti-inflammatory, analgesic and antimicrobial activities were evaluated. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. Some of the newly compounds exhibited better biological and pharmacological activities than the reference controls with low toxicity (LD50). The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. The detailed synthesis, spectroscopic data, LD50 and pharmacological activities of the synthesized compounds were reported.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 51, Issues 1â2, JulyâAugust 2012, Pages 7-17
Journal: International Journal of Biological Macromolecules - Volume 51, Issues 1â2, JulyâAugust 2012, Pages 7-17
نویسندگان
Saleh A. Bahashwan, Naif O. Al-Harbi, Ahmed A. Fayed, Abd El-Galil E. Amr, Khalid A. Shadid, Ali M. Alalawi, Ibrahim M.S. Bassati,