Al3+ ion cross-linked interpenetrating polymeric network microbeads from tailored natural polysaccharides

► Acid resistant chemical modification of locust bean gum was done. ► IPN microbeads were developed in a complete aqueous environment. ► pH sensitive release decreases the gastric side-effects of diclofenac sodium. ► Enhanced drug encapsulation efficiency. ► Avoid the use of toxic and hazardous chemicals and solvents during preparation.