In vitro and in vivo evaluation of oridonin-loaded long circulating nanostructured lipid carriers

► Poly(ethylene glycol)-coated nanostructured lipid carriers (PEG-NLC) for loading oridonin were successfully prepared. ► In vitro drug release of oridonin-loaded PEG-NLC exhibited biphasic drug release patterns with burst release initially and prolonged release afterwards. ► Oridonin-loaded PEG-NLC could prolong drug circulation time in blood.