Anti-diabetic activities of Acanthopanax senticosus polysaccharide (ASP) in combination with metformin

► Currently combination therapy had become very popular for the diabetes mellitus and its complications. ► A homogeneous polysaccharide (ASP) was extracted from A. senticosus. ► The antidiabetic effect of ASP combined with metformin in alloxan-induced diabetic mice was evaluated. ► ASP plus metformin had a more beneficial therapeutic efficacy for diabetes.