Anti-amyloidogenic and fibril-destabilizing effects of two manganese-salen derivatives against hen egg-white lysozyme aggregation

► Anti-amyloidogenic and disruptive effects of two salen derivatives, EUK-8 and EUK-134. ► The 3D structure determination of the molecular associates between lysozyme and the compounds. ► The interaction of aromatic rings of the compounds with the hydrophobic region of lysozyme. ► The higher efficiency of EUK-134 to either disrupt or inhibit the β-sheet structure. ► Essential role of hydrophobicity in anti-aggregating and dis-aggregating activities.