کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8335892 | 1540284 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural features and in vivo antitussive activity of the water extracted polymer from Glycyrrhiza glabra
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structural features and in vivo antitussive activity of the water extracted polymer from Glycyrrhiza glabra Structural features and in vivo antitussive activity of the water extracted polymer from Glycyrrhiza glabra](/preview/png/8335892.png)
چکیده انگلیسی
Antitussive drugs are amongst the most widely used medications worldwide; however no new class of drugs has been introduced into the market for many years. Herein, we have analyzed the water-extracted polymeric fraction (WE) of Glycyrrhiza glabra. This arabinogalactan protein enriched fraction, â¥85% of which gets precipitated with Yariv reagent, consisted mainly of 3- and 3,6-linked galactopyranosyl, and 5- and 3,5-linked arabinofuranosyl residues. Peroral administration of this polymer in a dose of 50 mg/kg body weight decreases the number of citric acid induced cough efforts in guinea pigs more effectively than codeine. It does not induce significant change in the values of specific airway resistance or provoked any observable adverse effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 48, Issue 4, 1 May 2011, Pages 634-638
Journal: International Journal of Biological Macromolecules - Volume 48, Issue 4, 1 May 2011, Pages 634-638
نویسندگان
Sudipta Saha, Gabriella Nosál'ová, Debjani Ghosh, Dana FleÅ¡ková, Peter Capek, Bimalendu Ray,