کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336107 | 1540431 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pattern of tyrosine hydroxylase expression during aging of mesolimbic pathway of the rat
ترجمه فارسی عنوان
الگوی بیان هیدروکسی آنزای تیروزین در طی زایش مسیر مزانولمبولی موش صحرایی
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کلمات کلیدی
paranigral nucleusRLISNCVPBPSNMPIFRRFcaudal linear nucleus of the rapheXSCPCLiIPCFasciculus retroflexusVTArSNCDMTGACANACTTHSNRSNLSubstantia nigra pars reticulataVTAsubstantia nigra - توده سیاهtyrosine hydroxylase - تیروزین هیدروکسیلازDopamine - دوپامینrubrospinal tract - رگروزپینالretrorubral field - زمینه بازتولیدAging - سالخوردگیdecussation of the superior cerebellar peduncle - قطع قاعده مفصلی مخچهMesolimbic pathway - مسیر MesolimbicBrain - مغزRat - موش صحراییventral tegmental area - ناحیه تگمنتوم شکمیNucleus accumbens - هسته accumbensinterpeduncular nucleus - هسته interpeduncularInterfascicular nucleus - هسته بین هسته ایanterior commissure - کمربند قدامی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Senescence is a physiological and progressive event that leads to the impairment of normal functions of the organism. The nervous system is one of the most affected systems during aging, presenting both structural and functional alterations associated with a decline in normal brain functions. In the present study we aimed to evaluate the impact of senescence on the mesolimbic pathway (nucleus accumbens - NAc and ventral tegmental area - VTA) of the rat, through immunohistochemistry for tyrosine hydroxylase (TH) enzyme, in young (3 months old), middle-aged (10 months old) and aged animals (18 months old). There was a significant decrease in the TH-immunoreactivity across NAc in aged animals as compared to the young and middle-aged ones, as revealed by optical densitometry. Medium and caudal regions of the VTA in the young animals possessed a higher number of TH-immunoreactive neurons as compared to the more aged groups. Comparisons among VTA regions in young animals revealed a difference in the number of cell bodies when the medium region was compared to the rostral and caudal regions whilst in both the middle-aged and aged groups comparisons between rostral vs caudal and medium vs caudal regions were significant. Our results show that aging impacts the mesolimbic pathway across its rostrocaudal axis, with a decrease of TH-reactivity in NAc and loss of neurons in VTA. These events may be involved with behavioral alterations observed throughout aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chemical Neuroanatomy - Volume 92, October 2018, Pages 83-91
Journal: Journal of Chemical Neuroanatomy - Volume 92, October 2018, Pages 83-91
نویسندگان
Bianca Norrara, Felipe P. Fiuza, Ana Cristina Arrais, Ianara Mendonça Costa, Jose Ronaldo Santos, Rovena Clara G.J. Engelberth, Jeferson Souza Cavalcante, Fausto Pierdoná Guzen, Jose Rodolfo Lopes P. Cavalcanti, Marco Aurelio M. Freire,