Fighting microbial infections: A lesson from amphibian skin-derived esculentin-1 peptides

- N-terminal derivatives of a frog skin peptide with anti-Pseudomonal/Candida activity.
- The mechanism relies on a fast membranolytic action on planktonic and biofilm forms.
- In vivo efficacy in murine models of lung/ocular Pseudomonas-induced infection.
- Ability to block Candida hyphal formation in a whole living organism.
- Promising candidates for new anti-infectives in human and veterinary medicine.