Nanoparticulate anatase TiO2 (TiO2 NPs) upregulates the expression of silkworm (Bombyx mori) neuropeptide receptor and promotes silkworm feeding, growth, and silking

- TiO2 NPs affect B. mori feeding and growth through increasing the expression of BmNPFR.
- TiO2 NPs enhance BmNPFR binding to its ligands BmNPF1a and BmNPF1b.
- BmNPFR is the primary and core target of TiO2 NPs' promotion of B. mori growth and development.
- TiO2 NPs have dose-dependent effects in different organs.