کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8348136 | 1541714 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?
ترجمه فارسی عنوان
آیا نقش لپتین در کاهش علائم افسردگی در هنگام کاهش وزن در دختران و پسران چاق وجود دارد؟
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کلمات کلیدی
افسردگی، لپتین، مقاومت لپتین، چاقی، نوجوانان، التهاب
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Several studies have sought to clarify the association between adolescent obesity and psychological distress. Recently, a biological link between leptin resistance and depression has been proposed. The aim of the present study was to examine changes in leptin concentrations as a potential predictor of reduced depression symptoms in obese adolescents during long-term interdisciplinary weight loss therapy. Seventy-five obese adolescents (age: 16.28 ± 2.37 years; BMI: 35.65 ± 4.64 kg/m2) engaged in a long-term interdisciplinary therapy for weight loss. They were evaluated at baseline and after 1 year of treatment for body composition, serum analyses and depression symptomatology. After therapy, body mass BMI, fat mass (% and kg), waist circumference, visceral, subcutaneous and visceral/subcutaneous fat and depression symptoms decreased and lean mass (%) increased significantly. There was an improvement in inflammatory profiles with a significant reduction in leptin and increase in adiponectin. Regression analyses showed that decreased leptin predicted amelioration in depression symptoms independent of age, gender and changes in visceral fat, body mass, fat mass (%) and leptin/adiponectin ratio. These associations appear stronger in girls than boys. The attenuation of hyperleptinemia appears to play an important role in the association between weight loss and depression, particularly in obese girls.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 65, March 2015, Pages 20-28
Journal: Peptides - Volume 65, March 2015, Pages 20-28
نویسندگان
Joana Pereira de Carvalho-Ferreira, Deborah Cristina Landi Masquio, Raquel Munhoz da Silveira Campos, Bárbara Dal Molin Netto, Flavia Campos Corgosinho, Priscila L. Sanches, Lian Tock, Sergio Tufik, Marco Túlio de Mello, Graham Finlayson,