Keywords: مقاومت لپتین; Obesity; Hypothalamus; Leptin; Leptin resistance; Blood-brain barrier; Leptin transport;
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Keywords: مقاومت لپتین; Mathematical modelling; Body fat regulation; Lipostat; Leptin; Leptin resistance; Feedback control;
Keywords: مقاومت لپتین; Peripheral CB1 blockade; Leptin resistance; POMC; NPY; Diet-induced obesity;
Keywords: مقاومت لپتین; Leptin biology; Leptin function; Leptin signaling; Leptin resistance; Energy homeostasis;
Keywords: مقاومت لپتین; Leptin pulsed delivery; Leptin resistance; STAT3;
Keywords: مقاومت لپتین; Feeding rhythm; Leptin resistance; Lipogenesis; Peripheral clockActb, Actin beta; Agrp, agouti related protein; HOMA-IR, homeostasis model assessment of insulin resistance; Npy, neuropeptide Y
Keywords: مقاومت لپتین; Arachidonic acid; Leptin resistance; Hypothalamus; Inflammation; Glucose metabolism; Lipid metabolism;
Keywords: مقاومت لپتین; Leptin; Leptin resistance; Obesity; Cellular signaling; Hypothalamus; Inflammation;
Keywords: مقاومت لپتین; Palmitic acid; Leptin resistance; Hypothalamus; Inflammation; Glucose metabolism; Lipid metabolism;
Keywords: مقاومت لپتین; Depression; Leptin; Leptin resistance; Obesity; Adolescents; Inflammation;
Keywords: مقاومت لپتین; leptin receptor; leptin resistance; obesity; diabetes; shedding; ADAM proteaseOB-R, leptin receptor; sOB-R, soluble leptin receptor; ADAM, a disintegrin and metalloprotease; GCSF, granulocyte-colony stimulating factor; LIF, leukemia inhibitory factor; JAK
Keywords: مقاومت لپتین; Leptin resistance; Leptin insufficiency; Blood–brain barrier; Pregnancy; SOCS3; Seasonality
Keywords: مقاومت لپتین; Leptin resistance; Obesity; Nonlinear model; Food intake regulation;
Keywords: مقاومت لپتین; AgRP; agouti-related protein; ARC; arcuate nucleus; ASCT2; glutamine/amino acid transporter 2; B0AT1; neutral amino acid transporter 1; BBB; blood-brain barrier; CCK; cholecystokinin; CNTF; ciliary neurotrophic factor; DIO; diet-induced obesity; MCT1; m
Keywords: مقاومت لپتین; AMPK; 5â²-adenosine monophosphate-activated protein kinase; BMI; body mass index; CHB; chronic hepatitis B; CHC; chronic hepatitis C; ChREBP; carbohydrate response element binding protein; Fox; forkhead box protein; HCC; hepatocellular carcinoma; HSCs;
Keywords: مقاومت لپتین; Leptin; Neurodegeneration; Obesity; Diabetes; Leptin resistance; Metabolic disorder;
Keywords: مقاومت لپتین; cytokines; mitochondria; neurogenesis; leptin resistance; diabetes; blood brain barrier
Keywords: مقاومت لپتین; Leptin; Maternal obesity; Placenta; Leptin resistance; Pregnancy complications;
Tub and β-catenin play a key role in insulin and leptin resistance-induced pancreatic beta-cell differentiation
Keywords: مقاومت لپتین; Beta-catenin; Beta-cell; Insulin resistance; Leptin resistance; Pancreatic islet-derived mesenchymal stem cell; Tub;
[D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, small molecule synthetic peptide leptin mimetics, improve glycemic control in diet-induced obese (DIO) mice
Keywords: مقاومت لپتین; AD; Alzheimer's Disease; AUC; area under the curve; BBB; blood-brain barrier; BMI; body mass index; CNS; central nervous system; DDM; dodecyl maltoside; DIO; diet-induced obese; HF; high-fat; LF; low-fat; OGTT; oral glucose tolerance test; PBS; phosphat
Research reportOral delivery of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics: Immunofluorescent localization in the mouse hypothalamus
Keywords: مقاومت لپتین; Blood-brain barrier; Leptin resistance; Leptin mimetics; Diet-induced obesity; Diabetes;
Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells
Keywords: مقاومت لپتین; Dehydroascorbic acid (DHAA); Leptin; Unfolded protein response (UPR); Leptin resistance; Endoplasmic reticulum (ER) stress; DHAA; dehydroascorbic acid; AA; ascorbic acid; UPR; unfolded protein response; ATF6; activating transcription factor 6; CHOP; C/EBP
SOCS3 expression within leptin receptor-expressing cells regulates food intake and leptin sensitivity but does not affect weight gain in pregnant mice consuming a high-fat diet
Keywords: مقاومت لپتین; Pregnancy; Leptin; Suppressor of cytokine signaling; Obesity; Leptin resistance; Hypothalamus
Original articleReprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity
Keywords: مقاومت لپتین; Body weight set point; Hypothalamus; Leptin; Leptin resistance; Obesity; PASylation; POMC;
QCM-4, a 5-HT3 receptor antagonist ameliorates plasma HPA axis hyperactivity, leptin resistance and brain oxidative stress in depression and anxiety-like behavior in obese mice
Keywords: مقاومت لپتین; Depression; Anxiety; Obesity; Leptin resistance; HPA-axis hyperactivity; Oxidative stress;
SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes a
Keywords: مقاومت لپتین; Leptin; Suppressor of cytokine signaling; Gestational diabetes; Obesity; Leptin resistance; HypothalamusARH, arcuate nucleus of the hypothalamus; DIO, diet-induced obesity; DMH, dorsomedial nucleus of the hypothalamus; EGWG, excessive gestational weight g
FTO is necessary for the induction of leptin resistance by high-fat feeding
Keywords: مقاومت لپتین; Fto; Leptin resistance; High-fat diet; NFкB; TRIP4; Hypothalamus; SOCS3GWAS, Genome-wide association studies; SNPs, single nucleotide polymorphisms; FTO, FaT mass and Obesity related; HFD, high-fat diet; MEF, Mouse embryonic fibroblasts; Y2H, Yeast two-hy
KBP-042 improves bodyweight and glucose homeostasis with indices of increased insulin sensitivity irrespective of route of administration
Keywords: مقاومت لپتین; Anti-diabetic; Insulin sensitivity; DACRA; Amylin analog; Weight-loss; Leptin resistance;
Hypothalamic ER stress: A bridge between leptin resistance and obesity
Keywords: مقاومت لپتین; Leptin resistance; POMC neurons; Hypothalamus; ER stress;
Low expression level of OB-Rb results from constitutive translocational attenuation attributable to a less efficient signal sequence
Keywords: مقاومت لپتین; VCAM-1; vascular endotherial cell adhesion molecule-1; PrP; prion protein; Prl; prolactin; JAK; Janus kinase; STAT; signal transducer and activator of transcription; SRP; signal recognition particle; Dox; doxycycline; TMD; transmembrane domain; PK; protei
Bariatric surgery to treat leptin resistant adolescent obesity: a success story
Keywords: مقاومت لپتین; Leptin; Leptin resistance; Adolescent obesity; Bariatric surgery;
Effects of chronic leptin infusion on subsequent body weight and composition in mice: Can body weight set point be reset?a a
Keywords: مقاومت لپتین; Leptin; Body weight “set-point”; Obesity; Leptin resistance
Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity a
Keywords: مقاومت لپتین; Suppressor of cytokine signaling-3; Type 2 diabetes mellitus; Leptin resistance; Hypothalamus; POMC; High-fat dietAP, area postrema; ARH, arcuate nucleus of the hypothalamus; DIO, diet-induced obesity; DMV, dorsal motor nucleus of the vagus; GTT, glucose
Cyclic AMP sensor EPAC proteins and energy homeostasis
Keywords: مقاومت لپتین; exchange protein directly activated by cAMP (EPAC); cAMP; energy balance; insulin secretion; leptin resistance
Advances in understanding the interrelations between leptin resistance and obesity
Keywords: مقاومت لپتین; Obesity; Leptin; Leptin resistance; Interrelations;
Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes
Keywords: مقاومت لپتین; Leptin resistance; Leptin gene delivery; STAT3;
The Relationship Between Leptin and Ventilatory Control in Heart Failure
Keywords: مقاومت لپتین; Cardiopulmonary exercise testing; ventilatory efficiency; leptin resistance
Spatial memory impairment and changes in hippocampal morphology are triggered by high-fat diets in adolescent mice. Is there a role of leptin?
Keywords: مقاومت لپتین; High-fat diet; Spatial memory; Dendritic spine density; Leptin resistance
Phenotypic effects of an induced mutation of the ObRa isoform of the leptin receptor ★
Keywords: مقاومت لپتین; ObRa; Leptin; Obesity; Leptin resistance; Glucose homeostasis; Blood brain barrier
Overview of the Physiology and Pathophysiology of Leptin With Special Emphasis on its Role in the Kidney
Keywords: مقاومت لپتین; Hyperleptinemia; leptin resistance; obesity; renal fibrosis
Endoplasmic reticulum stress and the on site function of resident PTP1B
Keywords: مقاومت لپتین; Unfolded Protein Response (UPR); Insulin resistance; Leptin resistance; Obesity; Diabetes mellitus;
Leptin replacement therapy does not improve the abnormal lipid kinetics of hypoleptinemic patients with HIV-associated lipodystrophy syndrome
Keywords: مقاومت لپتین; Triglycerides; HDL-C; Non-HDL-C; Lipolysis; Fat oxidation; Leptin resistance; HADL; HIV-associated dyslipidemic lipodystrophy; HDL-C; high density lipoprotein cholesterol; LDL-C; low density lipoprotein cholesterol; IDL-C; intermediate density lipoprotein
Leptin as mediator of the effects of developmental programming
Keywords: مقاومت لپتین; developmental programming; leptin; leptin resistance; obesity; metabolic syndrome; leptin antagonist
Leptin resistance develops spontaneously in mice during adult life in a tissue-specific manner. Consequences for hepatic steatosis
Keywords: مقاومت لپتین; STAT3; Akt; Leptin receptors; Leptin resistance; Liver;
Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats
Keywords: مقاومت لپتین; Leptin resistance; Gene therapy; High-fat feeding; Voluntary wheel running;
Behavioral and physiological effects of photoperiod-induced migratory state and leptin on a migratory bird, Zonotrichia albicollis: I. Anorectic effects of leptin administration
Keywords: مقاومت لپتین; Migration; Fat; Leptin; Food intake; Leptin resistance; Leptin receptor;
Neurobiology of overeating and obesity: The role of melanocortins and beyond
Keywords: مقاومت لپتین; Obesity; Leptin resistance; Addiction; Craving; Melanocortin
The hyperleptinemia and ObRb expression in hyperphagic obese rats
Keywords: مقاومت لپتین; Hyperleptinemia; Leptin resistance; Leptin receptor; Otsuka Long-Evans Tokushima Fatty rats;
Leptin in human physiology and therapeutics
Keywords: مقاومت لپتین; Leptin; Leptin deficiency; Obesity; Leptin resistance; Energy homeostasis; Insulin resistance; Adipokines; Amenorrhea; Lipoatrophy
Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice
Keywords: مقاومت لپتین; Leptin resistance; Hepatic lipids; High-fat diet;