کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6371885 1624013 2015 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A mathematical model of leptin resistance
ترجمه فارسی عنوان
مدل ریاضی مقاومت لپتین
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


- Mathematical model that describes leptin induced food-intake in rodents.
- Novel mechanism to introduce leptin resistance.
- Existence of diet-induced leptin resistance.

Obesity is often associated with leptin resistance, which leads to a physiological system with high leptin concentration but unable to respond to leptin signals and to regulate food intake. We propose a mathematical model of the leptin-leptin receptors system, based on the assumption that leptin is a regulator of its own receptor activity, and investigate its qualitative behavior. Based on current knowledge and previous models developed for body weight dynamics in rodents, the model includes the dynamics of leptin, leptin receptors and the regulation of food intake and body weight. It displays two stable equilibria, one representing a healthy state and the other one an obese and leptin resistant state. We show that a constant leptin injection can lead to leptin resistance and that a temporal variation in some parameter values influencing food intake can induce a change of equilibrium and a pathway to leptin resistance and obesity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 267, September 2015, Pages 10-23
نویسندگان
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