کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8348544 | 1541732 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Swimming training prevents fat deposition and decreases angiotensin II-induced coronary vasoconstriction in ovariectomized rats
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کلمات کلیدی
intrinsic heart rateSTOIngCoronary dysfunctionCPPOVXRASHRTACESTSROS - ROSswimming training - آموزش شناAngiotensin-converting enzyme - آنژیوتانسین تبدیل آنزیمAngiotensin II - آنژیوتانسین دوOvariectomy - اوفورکتومی، تخمدان برداریcoronary artery disease - بیماری عروق کرونرCardiovascular diseases - بیماری قلبی-عروقی analysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceRET - حقAng II - دومCVD - رسوب دهی شیمیایی بخار Renin angiotensin system - سیستم آنژیوتانسین رینینPME - شرکتهای کوچک و متوسطIHR - شماCAD - طراحی به کمک رایانه یا کَدcoronary perfusion pressure - فشار خون عروق کرونرperirenal - مرطوب کنندهphysical exercise - نرمشNitric oxide - نیتریک اکسیدhormone replacement treatment - هورمون جایگزین درمانbody weight - وزن بدنinguinal - پستاندارestrogen deficiency - کمبود استروژنReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Swimming training prevents fat deposition and decreases angiotensin II-induced coronary vasoconstriction in ovariectomized rats Swimming training prevents fat deposition and decreases angiotensin II-induced coronary vasoconstriction in ovariectomized rats](/preview/png/8348544.png)
چکیده انگلیسی
We investigated the effects of chronic swimming training (ST) on the deposition of abdominal fat and vasoconstriction in response to angiotensin II (ANG II) in the coronary arterial bed of estrogen deficient rats. Twenty-eight 3-month old Wistar female rats were divided into 4 groups: sedentary sham (SS), sedentary-ovariectomized (SO), swimming-trained sham (STS) and swimming-trained ovariectomized (STO). ST protocol consisted of a continuous 60-min session, with a 5% BW load attached to the tail, completed 5 days/week for 8-weeks. The retroperitoneal, parametrial, perirenal and inguinal fat pads were measured. The intrinsic heart rate (IHR), coronary perfusion pressure (CPP) and a concentration-response curve to ANG II in the coronary bed was constructed using the Langendorff preparation. Ovariectomy (OVX) significantly reduced 17-β-estradiol plasma levels in SO and STO groups (p < 0.05). The STO group had a significantly reduced retroperitoneal and parametrial fat pad compared with the SO group (p < 0.05). IHR values were similar in all groups; however, baseline CPP was significantly reduced in the SO, STS and STO groups compared with the SS group (p < 0.05). ANG II caused vasoconstriction in the coronary bed in a concentration-dependent manner. The SO group had an increased response to ANG II when compared with all other experimental groups (p < 0.05), which was prevented by 8-weeks of ST in the STO group (p < 0.05). OVX increased ANG II-induced vasoconstriction in the coronary vascular bed and abdominal fat pad deposition. Eight weeks of swimming training improved these vasoconstrictor effects and decreased abdominal fat deposition in ovariectomized rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 47, September 2013, Pages 29-35
Journal: Peptides - Volume 47, September 2013, Pages 29-35
نویسندگان
Patrick Wander Endlich, Erick Roberto Gonçalves Claudio, Washington Luiz da Silva Gonçalves, Sonia Alves Gouvêa, Margareth Ribeiro Moysés, Glaucia Rodrigues de Abreu,