C4 photosynthesis evolution: the conditional Mt. Fuji

In recent years, substantial progress has been made on firstly, the nature of enabling events and finally, quantitative models of C4 evolution that are based on C3-C4 intermediate species. I discuss the synthesis of these approaches as a consensus trajectory towards C4 photosynthesis and hypothesize on the effect of enabling factors on the fitness landscape of C4 evolution. A complete understanding of these mechanisms will require both further experimental studies and improved quantitative models of leaf physiology.