کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8384075 | 1543463 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ascidian sperm activating and attracting factor: Importance of sulfate groups for the activities and implication of its putative receptor
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
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![عکس صفحه اول مقاله: Ascidian sperm activating and attracting factor: Importance of sulfate groups for the activities and implication of its putative receptor Ascidian sperm activating and attracting factor: Importance of sulfate groups for the activities and implication of its putative receptor](/preview/png/8384075.png)
چکیده انگلیسی
The sperm activating and attracting factor (SAAF) from the eggs of the ascidian Cionaintestinalis was identified as the sulfated polyhydroxysterol,3α,4β,7α,26-tetrahydroxy-5α-cholestane-3,26-disulfate. We present a functional analysis of SAAF derivatives that reveals the roles of the various SAAF functional groups. Optical isomerism does not affect SAAF activities. Hydrolysis on one side, i.e. at the sulfate groups of SAAF, decreases the sperm-activating and sperm-attracting activities, while hydrolysis on both sides resulted in the loss of both activities. Biotinylated-SAAF lost its sperm-activating ability, but retained sperm-binding and chemotactic abilities. Thus, the sulfate groups of SAAF are responsible for these activities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issues 23â24, 15 October 2008, Pages 3429-3433
Journal: FEBS Letters - Volume 582, Issues 23â24, 15 October 2008, Pages 3429-3433
نویسندگان
Manabu Yoshida, Kogiku Shiba, Kaoru Yoshida, Hiroshi Tsuchikawa, Ouichirou Ootou, Toru Oishi, Michio Murata,