کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8384124 1543463 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brief cross-linking of Fas/APO-1 (CD95) triggers engulfment of pre-apoptotic target cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Brief cross-linking of Fas/APO-1 (CD95) triggers engulfment of pre-apoptotic target cells
چکیده انگلیسی
Macrophage clearance of dying cells is of crucial importance to maintain tissue homeostasis. Here, we show that brief treatment (15 min) of Jurkat T cells with agonistic anti-Fas antibodies or recombinant Fas ligand results in efficient phagocytosis by human monocyte-derived macrophages prior to the occurrence of common biomarkers of apoptosis. Similar findings were obtained when using primary human T cells. Macrophage engulfment of pre-apoptotic target cells was suppressed in the absence of serum. Moreover, pre-apoptotic cells secreted annexin I and administration of Boc1, a formyl peptide receptor/lipoxin receptor antagonist markedly attenuated their engulfment. Finally, pre-apoptotic Jurkat cells induced lower macrophage production of tumor necrosis factor-α and higher production of interleukin-10 in comparison to apoptotic target cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issues 23–24, 15 October 2008, Pages 3501-3508
نویسندگان
, , , ,