A mathematical immunochemoradiotherapy model: A multiobjective approach

This study developed a near optimization immunochemoradiotherapy model, which has three objectives; maximizing total weighted damage of cancer cells, minimizing total weighted side effect and minimizing total dose related therapy costs, originated from the Weapon–Target Assignment problem (WTA) of military operations research. The multi-objective structure is transformed into a single-objective format via goal programming. The presented model is a mixed-integer nonlinear goal programming model. A non-clinical hypothetical illustrative example is solved using MS Excel's Solver tool as a powerful spreadsheet tool. The theoretical result is extremely impressive especially compared with result of the single-objective program. The model facilitates cancer therapists to act in a multi-objective frame. However, the model is extremely needed to have clinical experiments to validate its theoretical power. This theoretical model is a virtuous synthesis of military and medical operations research.