Frequency of BRCA1 (185delAG and 5382insC) and BRCA2 (6174delT) mutations in Egyptian women with breast cancer compared to healthy controls

This study indicates that BRCA1 (185delAG) mutation might contribute to the incidence of breast cancer among Egyptian women, but not with BRCA1 (5382insC) and BRCA2 (6174delT) mutations. Furthermore, there was no significant association between these three founder mutations and the clinical presentation of BC among Egyptian women.