کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8395208 | 1544128 | 2015 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vagal efferent stimulation protects against Mesobuthus tamulus venom-induced acute respiratory distress syndrome in rats
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کلمات کلیدی
LPSP/FVESFiO2ARDSPaO2MBTPao2/Fio2 - Pao2 / Fio2α7 Nicotinic receptors - α7 گیرنده های نیکوتینAcute lung injury - آسیب ریه حادVentilator-induced lung injury - آسیب ریه ناشی از تهویهpulmonary edema - ادم ریهOleic acid - اسید اولئیکminute ventilation - تهویه ده دقیقهAcute respiratory distress syndrome - سندرم دیسترس تنفسی حادHeart rate - ضربان قلبrespiratory frequency - فرکانس تنفسیpartial pressure of oxygen in arterial blood - فشار جزئی اکسیژن در خون شریانیmean arterial pressure - فشار متوسط شریانیlipopolysaccharide - لیپوپلی ساکاریدmap - نقشهHypoxemia - هیپوکسمیVagotomy - واگوتومیVILI - ویلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
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چکیده انگلیسی
Mesobuthus tamulus (MBT) venom and oleic acid (OA) have been shown to produce acute respiratory distress syndrome (ARDS) involving different mechanisms. The role of vagally mediated anti-inflammatory pathway in ARDS is poorly understood. Therefore, the effects of vagal efferent stimulation on these two models of ARDS were examined. Experiments were performed on anesthetized adult rats. Parameters like ventilatory changes (respiratory frequency and minute ventilation), hypoxemic status (PaO2/FiO2 ratio; P/F ratio), survival time, pulmonary water content and histopathological evidences of lung injury were determined to assess the severity of ARDS. In addition, heart rate (HR) and mean arterial pressure (MAP) were monitored. Injection of OA/MBT venom produced respiratory alterations, hypoxemia, pulmonary edema and histopathological changes demonstrating the development of ARDS. In both the groups, animals died around 60 min. Tachypnea and hyperventilation were seen after OA while bradypnea and hypoventilation were seen after MBT venom. Pulmonary edema was absent in vagotomised animals in MBT venom group but not in OA group. Further, electrical stimulation of the cut peripheral ends of vagii prolonged the survival time and attenuated all the parameters of MBT venom-induced ARDS significantly. In case of OA, there was improvement in histopathological changes but the survival time of animals was not prolonged. Stimulation of α7-nicotinic receptors (by pretreatment with GTS-21) exacerbated OA as well as MBT venom-induced ARDS. The present results indicate that vagal efferent stimulation protects against MBT venom-induced ARDS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 108, 15 December 2015, Pages 189-201
Journal: Toxicon - Volume 108, 15 December 2015, Pages 189-201
نویسندگان
Aparna Akella, Shripad B. Deshpande,