کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8396794 1544159 2013 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Scorpion venom components that affect ion-channels function
ترجمه فارسی عنوان
اجزای سم عقرب که بر عملکرد کانال های یونی تأثیر می گذارند
کلمات کلیدی
تنوع زیستی، یون کانال، اثر کاربردی، توکسین عقرب، ویژگی های ساختاری،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی
The number and types of venom components that affect ion-channel function are reviewed. These are the most important venom components responsible for human intoxication, deserving medical attention, often requiring the use of specific anti-venoms. Special emphasis is given to peptides that recognize Na+-, K+- and Ca++-channels of excitable cells. Knowledge generated by direct isolation of peptides from venom and components deduced from cloned genes, whose amino acid sequences are deposited into databanks are nowadays in the order of 1.5 thousands, out of an estimate biodiversity closed to 300,000. Here the diversity of components is briefly reviewed with mention to specific references. Structural characteristic are discussed with examples taken from published work. The principal mechanisms of action of the three different types of peptides are also reviewed. Na+-channel specific venom components usually are modifier of the open and closing kinetic mechanisms of the ion-channels, whereas peptides affecting K+-channels are normally pore blocking agents. The Ryanodine Ca++-channel specific peptides are known for causing sub-conducting stages of the channels conductance and some were shown to be able to internalize penetrating inside the muscle cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 76, 15 December 2013, Pages 328-342
نویسندگان
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