Serum production against Tityus serrulatus scorpion venom using cross-linked chitosan nanoparticles as immunoadjuvant

► Chitosan nanoparticles obtained by ionic gelation method with TPP. ► Nanoparticles size 200 nm, maximum encapsulation efficiency and high antibody titers. ► Serum production against Tityus serrulatus scorpion venom. ► Chitosan nanoparticles applied as immunoadjuvant for serum production. ► Future serum production using antigens from snakes, spiders, wasps, frogs and bees.