کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8401173 | 1544481 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline](/preview/png/8401173.png)
چکیده انگلیسی
Echocardiography was used to estimate increased wall stress in failure, in vivo. Stretch of intact and skinned single myocytes revealed no effect on the Frank-Starling mechanism in failing myocytes. In isolated hearts acute stretch-induced arrhythmias occurred in all preparations. Significant shortening of the early APD was seen in control but not failing hearts. These observations may be linked to changes in the gene expression of candidate mechanosensitive ion channels (MSCs) TREK-1 and TRPC1/6. Computer simulations incorporating MSCs and changes in ion channels with failure, based on altered gene expression, largely reproduced experimental observations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Biophysics and Molecular Biology - Volume 115, Issues 2â3, August 2014, Pages 162-172
Journal: Progress in Biophysics and Molecular Biology - Volume 115, Issues 2â3, August 2014, Pages 162-172
نویسندگان
David Benoist, Rachel Stones, Alan P. Benson, Ewan D. Fowler, Mark J. Drinkhill, Matthew E.L. Hardy, David A. Saint, Olivier Cazorla, Olivier Bernus, Ed White,