Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery

Existing integrin drug targeting ligands, applied for the modification of drug molecules, drug carriers and CAR-T cells (CAR-T), in the context of wound healing, fibrosis or tumor stroma and their respective integrin targets. Dashed lines show potential integrin targets for existing ligands (PHSCNK, PR_b, RGD, RKK12, quinolonic, echistatin) that have not yet been used for targeting the respective cell line. In addition to already targeted integrins, integrins that have not yet been targeted but play a role in the pathology of wound healing, fibrosis or tumor stroma are presented.208