کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8402990 1544577 2015 28 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Basic biology and therapeutic implications of lncRNA
ترجمه فارسی عنوان
بیولوژی پایه و پیامدهای درمانی لنکرین
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی
A-Gene duplication and repurposing of pseudogenes is one of the proposed routes of lncRNA evolution. B-Mobile genetic elements (MGE) frequently initiate formation and evolution of new transcriptional units (TU) some of which become lncRNA. C-lncRNA participate in long range DNA looping essential for transcription regulation in somce loci. D-lncRNA are essential for telomere maintenance. E-lncRNA participate in X-chromosome inactivation and imprinting. F-lncRNA scaffold and regulate formation of nuclear paraspeckles, as a result also controlling the nuclear-cytoplasmic transport of mRNA. G-lncRNA are involved in formation of interchromatin granules enabling pre-mRNA splicing and maturation. H-Fine regulation of epigenetic modifications is assisted by tethering of epigenetic effectors and formation of polycomb bodies by lncRNA. I-Cytoplasmic roles of lncRNA include positive and negative regulation of mRNA stability. J-lncRNA are involved in regulation of translation and positive and negative regulation of nascent protein stability. K-lncRNA act as miRNA sponges blocking miRNA activity.137
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 87, 29 June 2015, Pages 15-24
نویسندگان
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