کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8402990 | 1544577 | 2015 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Basic biology and therapeutic implications of lncRNA
ترجمه فارسی عنوان
بیولوژی پایه و پیامدهای درمانی لنکرین
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
چکیده انگلیسی
A-Gene duplication and repurposing of pseudogenes is one of the proposed routes of lncRNA evolution. B-Mobile genetic elements (MGE) frequently initiate formation and evolution of new transcriptional units (TU) some of which become lncRNA. C-lncRNA participate in long range DNA looping essential for transcription regulation in somce loci. D-lncRNA are essential for telomere maintenance. E-lncRNA participate in X-chromosome inactivation and imprinting. F-lncRNA scaffold and regulate formation of nuclear paraspeckles, as a result also controlling the nuclear-cytoplasmic transport of mRNA. G-lncRNA are involved in formation of interchromatin granules enabling pre-mRNA splicing and maturation. H-Fine regulation of epigenetic modifications is assisted by tethering of epigenetic effectors and formation of polycomb bodies by lncRNA. I-Cytoplasmic roles of lncRNA include positive and negative regulation of mRNA stability. J-lncRNA are involved in regulation of translation and positive and negative regulation of nascent protein stability. K-lncRNA act as miRNA sponges blocking miRNA activity.137
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 87, 29 June 2015, Pages 15-24
Journal: Advanced Drug Delivery Reviews - Volume 87, 29 June 2015, Pages 15-24
نویسندگان
O. Khorkova, J. Hsiao, C. Wahlestedt,