کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8405777 | 1544897 | 2018 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of compound isolated from Lawsonia inermis (L.) (Myrtales: Lythraceae) on the immature stages of filarial vector Culex quinquefasciatus Say (Diptera: Culicidae) and its docking analysis with Acetylcholinesterase (AChE1)
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of compound isolated from Lawsonia inermis (L.) (Myrtales: Lythraceae) on the immature stages of filarial vector Culex quinquefasciatus Say (Diptera: Culicidae) and its docking analysis with Acetylcholinesterase (AChE1) Effect of compound isolated from Lawsonia inermis (L.) (Myrtales: Lythraceae) on the immature stages of filarial vector Culex quinquefasciatus Say (Diptera: Culicidae) and its docking analysis with Acetylcholinesterase (AChE1)](/preview/png/8405777.png)
چکیده انگلیسی
The aim of the present study was to evaluate the mosquito larvicidal activity of lawsone isolated from Lawsonia inermis (L). The larvae were exposed to four different concentrations of lawsone (0.5, 1.0, 1.5 and 2.0â¯ppm). After 24â¯h and 120â¯h post treatment the larval mortality and ovicidal activity were recorded. However, Lawsone shows significant larvicidal activity against Culex quinquefasciatus with LC50 and LC90 values of 0.72 and 5.04â¯ppm along with 84% of ovicidal activity at 2â¯ppm concentration. Histopathological study revealed that serious damage on the larval midgut cells. Lawsone showed no harmful effect on the tested organism Poecilia reticulata. Lawsone was highly active and inhibited AChE in a concentration dependent manner. Lawsone presented highest inhibition against AChE extracted from Cx. quinquefasciatus with IC50 of 0.69â¯Î¼g/mL. The chemical structure of lawsone was identified based on spectroscopic analysis and literature spectral data. Insect-specific cysteine residues of AChE1 inhibitors will not interact with AChE1 of other organisms. Computational analysis showed that lawsone made strong binding interaction with cysteine residue in the AChE1 of Cx. quinquefasciatus. Hence, these results suggested that lawsone might act as a mosquito specific AChE1 inhibitor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biocatalysis and Agricultural Biotechnology - Volume 15, July 2018, Pages 210-218
Journal: Biocatalysis and Agricultural Biotechnology - Volume 15, July 2018, Pages 210-218
نویسندگان
Sylvester Darvin Sandhanam, Pathalam Ganesan, Antony Stalin, Gabriel Paulraj Michael, Kedike Balakrishna, Perumal Pandikumar, Savarimuthu Ignacimuthu, Abdullah Al-Dhabi Naif,