کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8406505 | 1544943 | 2018 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modular assembling process of an in-silico protocell
ترجمه فارسی عنوان
پردازش تلفیقی مدولا پرولوکل در داخل سیلیکا
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کلمات کلیدی
رویکرد پایین به بالا، زیست شناسی مصنوعی، سلول مصنوعی، مهندسی سیستم ها، تحلیل سیستم، مدل سازی ریاضی، شبیه سازی،
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
مدلسازی و شبیه سازی
چکیده انگلیسی
The bottom-up approach of synthetic biology is driven by the need for a deepened understanding of the interaction of functional modules in living or artificial systems. The hope is that the gained knowledge will help to optimize existing systems, or, as one long-term goal of synthetic biology, to build up artificial cell-like entities from single building blocks. This article focuses on a system theoretic approach to synthetic biology, and in particular on the construction of a protocell model by the modular assembling process. Different models for an in-silico protocell are described that combines experimentally validated biological subsystems with theoretical assumptions. The in-silico protocell that is characterized consists of three different functional modules: the membrane proliferating module, the membrane contraction module, and a positioning module. Additional theoretical hypotheses are tested in order to merge the module models to one protocell model with synchronously working parts. The different approaches used here for developing a protocell model could be helpful for assembling the different modules to one system in reality. Depending on the objective one wants to achieve a more or less detailed modeling approach is appropriate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 165, March 2018, Pages 8-21
Journal: Biosystems - Volume 165, March 2018, Pages 8-21
نویسندگان
Eugenia Schneider, Michael Mangold,