کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8409611 1545107 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantitative metrics for drug-target ligandability
ترجمه فارسی عنوان
معیارهای کمی برای لیگادواد بودن دارو
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی
Ligandability is a prerequisite for druggability and is a much easier concept to understand, model and predict because it does not depend on the complex pharmacodynamic and pharmacokinetic mechanisms in the human body. In this review, we consider a metric for quantifying ligandability from experimental data. We discuss ligandability in terms of the balance between effort and reward. The metric is evaluated for a standard set of well-studied drug targets - some traditionally considered to be ligandable and some regarded as difficult. We suggest that this metric should be used to systematically improve computational predictions of ligandability, which can then be applied to novel drug targets to predict their tractability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 23, Issue 6, June 2018, Pages 1258-1266
نویسندگان
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