کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8409656 1545108 2018 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanomedicine safety in preclinical and clinical development: focus on idiosyncratic injection/infusion reactions
ترجمه فارسی عنوان
ایمنی نانو در پیشرفت پیش از موعد و بالینی: تمرکز بر روی واکنش های تزریق / تزریق فردا
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی
Injection/infusion reactions to nanopharmaceuticals (and particulate drug carriers) are idiosyncratic and well documented. The molecular basis of nanoparticle-mediated injection reactions is debatable, with two hypotheses as front-runners. The first is complement-activation-related 'pseudoallergy', where a causal role for nanoparticle-mediated complement activation in injection/infusion reactions is considered. However, the second hypothesis (the rapid phagocytic response hypothesis) states a transitional link from robust clearance of nanoparticles (NPs) from the blood by strategically placed responsive macrophages to adverse hemodynamic and cardiopulmonary reactions, regardless of complement activation. Here, I critically examine and discuss these hypotheses. Current experimentally derived evidence appears to be more in support of the rapid phagocytic response hypothesis than of the 'pseudoallergy' hypothesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 23, Issue 5, May 2018, Pages 1034-1042
نویسندگان
,