Therapeutic potential of neuregulin-1 in cardiovascular disease

► Neuregulin (NRG)-1 regulates myocardial function. ► NRG-1 regulates vascular function. ► Disabled NRG-1/ErbB signaling is implicated in the progression of heart failure. ► Animal studies showed the therapeutic effects of NRG-1 in heart failure. ► Clinical trials showed therapeutic potential of recombinant human NRG-1 in heart failure.