Targeting VEGF signalling via the neuropilin co-receptor

► Neuropilin-1 is a VEGF receptor that is involved in tumour growth and angiogenesis. ► Structural biology of neuropilins supports the discovery of new therapeutics. ► Neuropilin-1-specific small molecule antagonists of VEGF-A are under development. ► Short peptides targeting neuropilin-1 are being explored as a drug-delivery system.