The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications

► The AhR is a transcription factor activated by diverse exogenous compounds. ► The AhR regulates the expression of xenobiotic metabolism genes. ► KO models have revealed that the AhR also regulates endogenous processes. ► AhR modulators might be used as anti-tumorigenic or anti-inflammatory drugs. ► The AhR also regulates the proliferation of hematopoietic stem cells.