Torching the Haystack: modelling fast-fail strategies in drug development

► Fast-fail strategies focus on clearing the development pipeline freeing up resources for more promising molecules. ► Fast-fail strategies are directed at reducing late-stage attrition rather than minimizing cycle time. ► Fast-fail strategies reduce expected times in the pipeline. ► Fast-fail strategies reduce expected development costs. ► Fast-fail strategies increase R&D productivity - the number of NMEs/year/$bn. ► Allocate resources earlier in the development life-cycle to reduce attrition rates.