Transcriptional data: a new gateway to drug repositioning?

► Can every biological state be represented by a given gene expression signature? ► Recently, signatures have been used as proxies of clinicopathological phenotypes. ► Drug-drug/drug-disease 'connections' have been inferred by signature matching. ► This allowed the prediction of new application for already approved drugs. ► A massive amount of public transcriptional data is ready to be exploited in this way.