A modern in vivo pharmacokinetic paradigm: combining snapshot, rapid and full PK approaches to optimize and expedite early drug discovery

► Three tiered in vivo rodent PK approaches (snapshot, rapid and full PK studies) at GNF are described. ► Applications and utilities of each in vivo PK approach are discussed. ► PK approaches expedite compound profiling and guide selection into efficacy models. ► Integration of tiered in vitro and in vivo PK approaches into drug discovery paradigm is highlighted.