کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8411021 1545230 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systems pharmacology of hepatic metabolism in zebrafish larvae
ترجمه فارسی عنوان
فارماکولوژی سیستم متابولیسم کبدی در لاروهای زرگری
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی
Interspecies translation of pharmacological processes needs to improve to reduce attrition in drug development. Systems pharmacology integrates systems biology and pharmacometrics to characterise and quantify system-specific behaviour upon exposure to drugs in different species. The zebrafish is a suitable vertebrate model organism for systems pharmacology, combining high-throughput potential with high genetic homology to higher vertebrates. Zebrafish larvae have been increasingly used for drug screens, but the influence of internal drug and metabolite exposure is hardly studied. Quantifying this internal exposure is essential for establishing both exposure-response and dose-exposure relationships, needed for translation. The zebrafish may also serve as a suitable model species for translational studies on the occurrence of hepatotoxicity and the influence of hepatic dysfunction on drug metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today: Disease Models - Volume 22, Winter 2016, Pages 27-34
نویسندگان
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