کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8411160 1545248 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of carbon-11 labelled tool compounds in support of drug development
ترجمه فارسی عنوان
استفاده از ترکیبات ابزار دارای کربن 11 در حمایت از توسعه دارو
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی
The pharmaceutical industry is facing key challenges to improve return on R&D investment. Positron emission tomography (PET), by itself or in combination with complementary technologies such as magnetic resonance imaging (MRI), provides a unique opportunity to confirm a candidate's ability to meet the so-called 'three pillars' of drug development. Positive confirmation provides confidence for go/no-go decision making at an early stage of the development process and enables informed clinical progression. Whereas fluorine-18 has probably gained wider use in the community, there are benefits to using carbon-11 given the greater flexibility the use of this isotope permits in adaptive clinical study design. This review explores the scope of available carbon-11 chemistries and provides clinical examples to highlight its value in PET studies in support of drug development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today: Technologies - Volume 25, November 2017, Pages 3-10
نویسندگان
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