کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8411400 1545261 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biofilms as a mechanism of bacterial resistance
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Biofilms as a mechanism of bacterial resistance
چکیده انگلیسی
Inside the biofilm, antimicrobial agents must overcome high cell density, an increased number of resistant mutants, substance delivery, molecular exchanges, such as high levels of beta-lactamases or inducers of efflux pump expression, and specific adaptive cells, so-called persisters. The environment within the biofilm modulates the response to antibiotics, especially when the SOS response or DNA repair systems are involved. Exposure to subinhibitory concentrations of antibiotics can enhance biofilm formation and mutagenesis. Thus, a global response to cell stress seems to be responsible for antibiotic-induced biofilm formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today: Technologies - Volume 11, March 2014, Pages 49-56
نویسندگان
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