کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8416796 | 1545651 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Relationship between the frequency of influenza vaccination and cell-mediated immunity
ترجمه فارسی عنوان
ارتباط بین فراوانی واکسیناسیون آنفلوآنزا و مصونیت از طریق سلول
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کلمات کلیدی
GMTIFN-γCMIHAIIIV - 7Neutralizing antibody - آنتی بادی غیرطبیعیCell-mediated immunity - ایمنی سلولیinterferon-γ - اینترفرون-γhemagglutination inhibition - مهار هموگلوبینGeometric mean titer - میانگین میانگین هندسیinfluenza vaccine - واکسن آنفلوآنزاInactivated influenza vaccine - واکسن آنفلوآنزا غیر فعال شده است
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
چکیده انگلیسی
Despite established guidelines for population-level assessments of immunity after vaccination, standard methods for individual-level analyses have not been established, limiting the ability to optimize vaccination strategies within a particular season. In this study, we evaluated changes in cell-mediated immunity (CMI) with respect to the number of influenza vaccine doses. In particular, the influenza vaccine was administered to 21 adults during the 2015-2016 season. IFN-γ production induced by the influenza vaccine antigens [A (H1N1), A (H3N2), B (Yamagata lineage), and B (Victoria lineage)] increased after the first dose of vaccination in 11, 10, 10, and 11 subjects, respectively. In 5 of 10 (H1N1), 4 of 10 (H3N2), 3 of 9 (Yamagata lineage), and 3 of 8 (Victoria lineage) subjects who did not exhibit an increase in IFN-γ production after the first dose, CMI was enhanced after the second dose. The production of IFN-γ increased after the first or second dose of the vaccine in 16, 14, 13, and 14 of the 21 subjects, respectively. The results of this study showed that two doses of the influenza vaccine effectively enhance CMI in subjects with primary vaccine failure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Immunological Methods - Volume 458, July 2018, Pages 58-62
Journal: Journal of Immunological Methods - Volume 458, July 2018, Pages 58-62
نویسندگان
Naruhito Otani, Masayuki Shima, Takashi Ueda, Kaoru Ichiki, Kazuhiko Nakajima, Yoshio Takesue, Kenta Honjo, Natsuko Yoshida, Sayo Kawata, Toshiomi Okuno,