In vivo depletion and genetic targeting of mouse intestinal CX3CR1+ mononuclear phagocytes

CD11chi CD103+ CD11b− DCs (green), CD103+ CD11b+ DCs (blue) and CD103− CD11b+ MPs (red) are distributed throughout the mucosa. CD103+ CD11b+ DCs and CD103− CD11b+ MPs can be associated with the intestinal epithelium (yellow), whereas CD103+ CD11b− DCs are found in the deeper mucosa and are likely localized to the isolated lymphoid follicles (ILFs) (Bogunovic et al., 2009; Koscso et al., 2015). CD103− CD11b+ MPs are further divided into CX3CR1hi Mϕs that are tissue-resident, and CX3CR1int MPs that migrate to the MLNs similar to CD103+ CD11b− and CD103+ CD11b+ DCs. CD11clo CD103− CD11b+ Mϕs are distributed in the muscularis externa along the myenteric plexus formed by enteric neurons (black).